PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
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PROTAC Linkers Related Products (4114)
Related Products (4114)
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PROTAC Linkers Isoform Comparison
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Benzyl 2-(4-(bromomethyl)phenyl)acetate
0 ImagesCat. No.: HY-W651679CAS No.: 140233-65-4
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Ethyl 11-bromoundecanoate
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Piperazin-C3-OH dihydrochloride
0 ImagesCat. No.: HY-W115358CAS No.: 6427-02-7
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Boc-azetidine-piperazin dihydrochloride
0 ImagesCat. No.: HY-W130126CAS No.: 2061980-49-0
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tert-Butyl (7-oxoheptyl)carbamate
0 ImagesCat. No.: HY-24256CAS No.: 133728-25-3
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4-(4-Piperidyl)-1-butanol
0 ImagesCat. No.: HY-33023CAS No.: 57614-92-3Synonyms: 4-Piperidinebutanol
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17-((tert-Butoxycarbonyl)amino)heptadecanoic acid
0 ImagesCat. No.: HY-W883922CAS No.: 2443488-63-7
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tert-Butyl N-(2-azaspiro[3.3]heptan-6-yl)carbamate hydrochloride
![tert-Butyl N-(2-azaspiro[3.3]heptan-6-yl)carbamate hydrochloride](https://file.medchemexpress.com/product_pic/hy-20239a.gif "Click to View tert-Butyl N-(2-azaspiro[3.3]heptan-6-yl)carbamate hydrochloride Product Detail")
0 ImagesCat. No.: HY-20239ACAS No.: 1956355-97-7
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1-(1-(3-Chloropropyl)piperidin-4-yl)ethan-1-ol
0 ImagesCat. No.: HY-W357971CAS No.: 49620-32-8
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Benzyl (6-aminohexyl)carbamate hydrochloride
0 ImagesCat. No.: HY-W097113CAS No.: 78618-06-1
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1-(Piperidin-4-yl)azetidin-3-ol dihydrochloride
0 ImagesCat. No.: HY-W248194CAS No.: 1537465-19-2
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Di-tert-butyl decanedioate
0 ImagesCat. No.: HY-W415282CAS No.: 143050-66-2
![3,9-Diazaspiro[5.5]undecane-3-carboxylic acid](https://file.medchemexpress.com/product_pic/hy-168912.gif "Click to View 3,9-Diazaspiro[5.5]undecane-3-carboxylic acid Product Detail")
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tert-Butyl 4-(2-Aminoethyl)-3,3-difluoropiperidine-1-carboxylate
0 ImagesCat. No.: HY-W001731CAS No.: 1334412-45-1
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N-(m-PEG9)-N'-(PEG5-acid)-Cy5
0 ImagesCat. No.: HY-141037CAS No.: 2107273-26-5
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Cbz-PEG4-NH2
0 ImagesCat. No.: HY-W588712CAS No.: 2708281-05-2
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Tert-butyl (7-iodoheptyl)carbamate
0 ImagesCat. No.: HY-W399350CAS No.: 474886-85-6
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TBS-PEG5-OH
0 ImagesCat. No.: HY-W552310CAS No.: 393174-68-0
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Methyl 5-oxopentanoate
0 ImagesCat. No.: HY-W614268CAS No.: 6026-86-4
